The University of Konstanz is one of eleven Universities of Excellence in Germany. Since 2007 it has been successful in the German Excellence Initiative and its follow-up programme, the Excellence Strategy.
In our group we investigate the key pathways which control neuronal cell death. In this contest we are seeking for an enthusiastic person to start a doctoral research project on understanding how the ensemble of metabolites determines whether a toxicant leads to the demise of an entire cell by apoptosis or by a non-apoptotic death (e.g. ferroptosis) or to a selective neurite degeneration. The project will be part of collaborative Research Centers/Transregio (SFB-TRR 353), dedicated to the research of biological processes that regulate the phenomenon of cell death at the molecular level. The Transregio project will offer you the opportunity to work in collaboration with several groups involved in the collaborative Research Centers, thus giving you the opportunity to exchange expertise and skills with other colleagues. Joining Konstanz University, you will achieve your PhD in one of the top-level research University in German, with a great international and interdisciplinary environment, nevertheless a great place for work-life balance with our campus perched on a hilltop overlooking Konstanz with a great view of Lake Constance and the Alps.
Two positions are available within the group of Prof. M. Leist; indeed, the question of metabolism-dependent decisions in the cell death process will be addressed on two tiers. In project A, it will be explored how cell death is triggered by toxicants under two standard metabolic situations that differ in the way cellular energy is provided. In project B, it will be explored whether interventions in key metabolic controllers or metabolite levels can lead to transitions between cell death modes. Although interplaying data and findings, the two projects will be pursued in parallel and independently.
We look forward to receiving your application with the usual documents until 31.10.2023 via our Online Application Portal.